Year: 2021 | Month: February | Volume 11 | Issue 1
Evaluation of Anthelmintic Activity of Butea frondosa (Koeing ex Roxb.) Seeds Extracts Against Benzimidazole Resistant Caprine Gastrointestinal Nematodes
Rupanjali Saiyam
Giridhari Das
Suman Kumar
Rupesh Verma
Kshemankar Shrman
Shashi Pradhan
Kusum Lata
Siddhant Bendigeri
DOI:10.30954/2277-940X.01.2021.5
Abstract:
The present investigation was carried out to evaluate the anthelmintic efficacy of crude aqueous and methanolic extract of Butea frondosa seeds extracts against benzimidazole resistant gastrointestinal nematodes of goats through in vitro and in vivo methods. In vitro investigation was carried out by egg hatch assay (EHA), larval paralysis test (LPT) and adult mortality test (AMT) against different stages of gastrointestinal nematodes whereas, in vivo by faecal egg count reduction (FECR) test in goats naturally infected with benzimidazole resistant GI nematodes. In in vitro trial, methanolic extract showed better ED50 in egg hatch assay and larval paralysis test as compared to aqueous extract. Moreover, in adult mortality tests, the methanolic extract gave better average corrected mortality as compared to aqueous extract. In vivo results revealed that the group treated with methanolic extracts showed the significant reduction (p<0.05) on 21st day whereas, the group treated with aqueous extract showed the highest and significant reduction (p<0.01) on 14th day. The results of both in vitro and in vivo trials suggest that B. frondosa possess anthelmintic activity and could be considered as one of the alternatives to the chemical anthelmintic.
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